Glucose metabolism in vertebrate retinas is dominated by aerobic glycolysis (the “Warburg
Effect”), which allows only a small fraction of glucose-derived pyruvate to enter mitochondria. …

Mutations in the Joubert syndrome-associated small GTPase ARL13B are linked to
photoreceptor impairment and vision loss. To determine the role of ARL13B in the development, …

Mutations in the gene coding for AIPL1 cause Leber congenital amaurosis (LCA), a severe
form of childhood blindness. The severity in disease is reflected in the complete loss of vision …

Leber congenital amaurosis (LCA) caused by mutations in Aryl hydrocarbon receptor
interacting protein like-1 ( Aipl1) is a severe form of childhood blindness. At 4 weeks of age, a …

We have determined the crystal structure of a novel regulatory protein (MGP-40) from the
mammary gland. This protein is implicated as a protective signaling factor that determines …

Bardet-Biedl syndrome (BBS) is a genetic disorder affecting multiple systems and organs in
the body. Several mutations in genes associated with BBS affect only photoreceptor cells …

Despite mounting evidence that the mammalian retina is exceptionally reliant on proper NAD+
homeostasis for health and function, the specific roles of subcellular NAD+ pools in retinal …

In rod photoreceptors, several phototransduction components display light-dependent
translocation between cellular compartments. Notably, the G protein transducin translocates from …

Prenylation is the posttranslational modification of a carboxyl-terminal cysteine residue of
proteins that terminate with a CAAX motif. Following prenylation, the last three amino acids are …

Defects in the photoreceptor-specific gene encoding aryl hydrocarbon receptor interacting
protein like-1 (AIPL1) are linked to blinding diseases, including Leber congenital amaurosis (…