Here we describe a method for fabricating a primary human Small Intestine-on-a-Chip (Intestine
Chip) containing epithelial cells isolated from healthy regions of intestinal biopsies. The …

The diverse bacterial populations that comprise the commensal microbiome of the human
intestine play a central role in health and disease. A method that sustains complex microbial …

… Author links open overlay panel Amir Bein 1 a , Woojung Shin 2 a , Sasan Jalili-Firoozinezhad
1 3 , Min Hee Park 2 , Alexandra Sontheimer-Phelps 1 4 , Alessio Tovaglieri 1 5 , Angeliki …

Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …

Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we …

Injectable hydrogels that resemble electromechanical properties of the myocardium are crucial
for cardiac tissue engineering prospects. We have developed a facile approach that uses …

The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology under
myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a …

The liver is the largest internal organ of the body with complex microarchitecture and function
that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver injury (…

Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely
on use of animal models because culture systems do not faithfully mimic human intestinal …

Background & Aims The mucus layer in the human colon protects against commensal
bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal …