Cohort profile: Tohoku medical megabank project birth and three-generation cohort study (TMM BirThree cohort study): rationale, progress and perspective

…, K Suzuki, N Ishii, S Ogishima, S Mizuno… - International journal …, 2020 - academic.oup.com
Although a large sample size is useful for the elucidation of what is called ‘missing heritability’,
which is an unexplained part of a total phenotypic variance in a quantitative trait or …

Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2

…, Y Yamakawa, Y Matsuo, J Minowada, S Mizuno… - Immunology letters, 1996 - Elsevier
We purified a neutrophil chemotactic factor from a culture fluid of the PHA-activated human T-cell
leukemia SKW-3 cells. The factor showed a 16-kDa basic protein by Tricin-SDS-…

[HTML][HTML] AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease

S Mizuno, R Iijima, S Ogishima, M Kikuchi… - BMC systems …, 2012 - Springer
Background Alzheimer’s disease (AD) is the most common cause of dementia among the
elderly. To clarify pathogenesis of AD, thousands of reports have been accumulating. However…

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway

…, S Yamagoe, Y Murakami, K Suzuki, S Mizuno… - Oncogene, 1997 - nature.com
While most untransformed cells require substrate attachment for growth (anchorage
dependence), the oncogenic transformed cells lack this requirement (anchorage independence) …

Macular carotenoid levels of normal subjects and age-related maculopathy patients in a Japanese population

A Obana, T Hiramitsu, Y Gohto, A Ohira, S Mizuno… - Ophthalmology, 2008 - Elsevier
PURPOSE: Macular carotenoid pigments composed of lutein and zeaxanthin are thought to
affect the development of age-related maculopathy (ARM). Macular carotenoid levels were …

Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver

S Yamagoe, S Mizuno, K Suzuki - … et Biophysica Acta (BBA)-Gene Structure …, 1998 - Elsevier
We previously reported the purification and amino acid sequence of a novel neutrophil
chemotactic protein termed LECT2 (leukocyte cell-derived chemotaxin 2). In this paper we report …

Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds

…, H Fukazawa, Y Murakami, S Mizuno - … and biophysical research …, 1989 - Elsevier
Herbimycin A, an antibiotic which reverses Rous sarcoma virus transformation, inhibited
irreversibly the auto- and transphosphorylation activities of p60 v-src inin vitro immune complex …

Inhibition of DNA-dependent RNA synthesis by rifamycins

H Umezawa, S Mizuno, H Yamazaki… - The Journal of …, 1968 - jstage.jst.go.jp
… Hamao Umezawa Satoshi Mizuno Hisaji Yamazaki Kazuo Nitta National … Mizuno, S.; H,
Yamazaki, K. Nitta & H. Umezawa : Inhibition of initiation of … Mizuno, S.; H. Yamazaki, K. Nitta & H. …

Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A

Y Uehara, Y Murakami, S Mizuno, S Kawalt - Virology, 1988 - Elsevier
We studied the effectiveness of herbimycin A, an inhibitor of the function of the temperature-sensitive
src oncogene, to reverse the morphologies of chicken and mammalian cells …

Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro

…, L Pei-Mlng, Y Chii, M Yuko, M Satoshi… - Biochemical …, 1991 - Elsevier
Herbimycin A is an antibiotic which reverses transformation caused by various src related
oncogenes. The reversion of transformation is restricted to cells transformed by tyrosine kinase …