The sympathetic nervous system is designed to respond to stress. Adenylyl cyclase (AC) is
the keystone of sympathetic transmission, yet its role in response to acute overload in the …

The open-system degassing of magma controls the bifurcation of explosive and non-explosive
volcanism. Permeable gas flow through connected bubbles is a potentially important …

The microstructure of bubbles in magma controls the dynamics of magma flow in a volcanic
conduit. To investigate the shear‐induced evolution of bubble microstructures, we performed …

Purpose: We developed a complex of tumor antigen protein with a novel nanoparticle
antigen delivery system of cholesteryl pullulan (CHP). To target HER2 antigen, we prepared …

Various neurotransmitters, such as dopamine, stimulate adenylyl cyclase to produce cAMP,
which regulates neuronal functions. Genetic disruption of the type 5 adenylyl cyclase isoform …

PKA phosphorylates multiple molecules involved in calcium (Ca 2+ ) handling in cardiac
myocytes and is considered to be the predominant regulator of β-adrenergic receptor–mediated …

In a genetically engineered mouse line with disruption of type 5 adenylyl cyclase (AC5 −/− ),
a major cardiac isoform, there was no compensatory increase in other isoforms of AC in the …

We previously investigated the utility of μ-oxo N,N′- bis(salicylidene)ethylenediamine iron (Fe(Salen))
nanoparticles as a new anti-cancer agent for magnet-guided delivery with anti-…

Background— Desensitization of the cyclic adenosine monophosphate signal protects cardiac
myocytes against catecholamine stress, thus preventing the development of apoptosis. …

The recent success of chimeric antigen receptor (CAR)-T cell therapy for treatment of
hematologic malignancies supports further development of treatments for both liquid and solid …