While isolated motor actions can be correlated with activities of neuronal networks, an
unresolved problem is how the brain assembles these activities into organized behaviors like …

High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major
challenge in neuroscience. Here we demonstrate simultaneous functional imaging of …

Many neurons release classical transmitters together with neuropeptide co-transmitters
whose functions are incompletely understood. Here we define the relationship between two …

Animals track fluctuating stimuli over multiple timescales during natural olfactory behaviors.
Here, we define mechanisms underlying these computations in Caenorhabditis elegans. By …

To the Editor—Cutting-edge innovations in biological microscopy are increasingly blurring
the line between data acquisition and data analysis. Computational microscopy and machine-…

Neuroscience relies on techniques for imaging the structure and dynamics of neural circuits,
but the cell bodies of individual neurons are often obscured by overlapping fluorescence …

The wiring architecture of neuronal networks is assumed to be a strong determinant of their
dynamical computations. An ongoing effort in neuroscience is therefore to generate …

Animals with complex nervous systems demand sleep for memory consolidation and synaptic
remodeling. Here, we show that, although the Caenorhabditis elegans nervous system …

10.7554/eLife.14116.001 In animal locomotion a tradeoff exists between stereotypy and
flexibility: fast long-distance travelling (LDT) requires coherent regular motions, while local …

Cerebral organoids provide unparalleled access to human brain development in vitro.
However, variability induced by current culture methodologies precludes using organoids as …