The role of bone marrow adipocytes in cancer progression: the impact of obesity
M Hernandez, S Shin, C Muller, C Attané - Cancer and Metastasis Reviews, 2022 - Springer
Bone marrow adipose tissues (BMATs) and their main cellular component, bone marrow
adipocytes (BMAds), are found within the bone marrow (BM), which is a niche for the …
adipocytes (BMAds), are found within the bone marrow (BM), which is a niche for the …
Translational alterations in pancreatic cancer: a central role for the integrated stress response
S Shin, J Solorzano, M Liauzun, S Pyronnet… - NAR …, 2022 - academic.oup.com
mRNA translation is a key mechanism for cancer cell proliferation and stress adaptation.
Regulation of this machinery implicates upstream pathways such as PI3K/AKT/mTOR, RAS/MEK…
Regulation of this machinery implicates upstream pathways such as PI3K/AKT/mTOR, RAS/MEK…
[HTML][HTML] eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer
D Müller, S Shin, TG de Rugy, R Samain, R Baer… - JCI insight, 2019 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) relies on hyperactivated protein synthesis.
Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR …
Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR …
Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer
S Shin, R Nicolle, C Jean, R Samain, M Ayadi… - bioRxiv, 2020 - biorxiv.org
Molecular profiling of Pancreatic Ductal Adenocarcinoma (PDA), based on transcriptomic
analyses, identifies two main prognostic subtypes (basal-like and classical), but does not allow …
analyses, identifies two main prognostic subtypes (basal-like and classical), but does not allow …
RNA G-quadruplex dynamic steers the crosstalk between protein synthesis and energy metabolism
L Dumas, S Shin, Q Rigaud, M Cargnello… - bioRxiv, 2024 - biorxiv.org
Cancer cells rely on mitochondria for their bioenergetic supply and macromolecule synthesis.
Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which …
Central to mitochondrial function is the regulation of mitochondrial protein synthesis, which …
Abstract PO-088: Classification based on efficiency of mRNA translation reveals a metabolically-dependent subtype of pancreatic cancer
S Shin, R Nicolle, M Liauzun, J Solorzano, A Brunel… - Cancer Research, 2021 - AACR
Molecular profiling of Pancreatic Ductal Adenocarcinoma (PDA), based on transcriptomic
analyses, identifies two main prognostic subtypes (basal-like and classical), but does not allow …
analyses, identifies two main prognostic subtypes (basal-like and classical), but does not allow …
[HTML][HTML] A novel 3D culture model for human primary mammary adipocytes to study their metabolic crosstalk with breast cancer in lean and obese conditions
M Rebeaud, C Bouche, S Dauvillier, C Attané… - Scientific Reports, 2023 - nature.com
Obesity is a negative prognosis factor for breast cancer. Yet, the biological mechanisms
underlying this effect are still largely unknown. An emerging hypothesis is that the transfer of free …
underlying this effect are still largely unknown. An emerging hypothesis is that the transfer of free …
Pancreas cancer meets the thunder god
SR Hingorani, JD Potter - Science translational medicine, 2012 - science.org
A new formulation of a natural product shows remarkable activity against pancreatic ductal
adenocarcinoma across a number of preclinical model systems. These findings set the stage …
adenocarcinoma across a number of preclinical model systems. These findings set the stage …
[CITATION][C] Translational control of DNA replication by 4E-BP1 in pancreatic cancer
D Müller, TG de Rugy, S Shin, R Samain, R Baer… - Pancreatology, 2018 - Elsevier
[CITATION][C] Loss of 4E-BP1-mediated translational control favors DNA replication in pancreatic cancer.
D Müller, TG de Rugy, R Saamin, S Shin, R Baer… - Pancreatology, 2017 - Elsevier