Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure 1
by providing human cardiomyocytes to support heart regeneration 2 . Studies of human …

The naïve pluripotent state has been shown in mice to lead to broad and more robust
developmental potential relative to primed mouse epiblast cells. The human naïve ES cell state …

High-throughput methods based on chromosome conformation capture have greatly advanced
our understanding of the three-dimensional (3D) organization of genomes but are limited …

The present study examined factors that are associated with an individual’s adherence to
rape myths at two colleges located in the same town. Particularly, we examined sex, race, and …

Steering the differentiation of induced pluripotent stem cells (iPSCs) toward specific cell
types is crucial for patient-specific disease modeling and drug testing. This effort requires the …

Sickle cell disease and β-thalassemia are common monogenic disorders that cause
significant morbidity and mortality globally. The only curative treatment currently is allogeneic …

The folding and three-dimensional (3D) organization of chromatin in the nucleus critically
impacts genome function. The past decade has witnessed rapid advances in genomic tools for …

To easily edit the genome of naïve human embryonic stem cells (hESC), we introduced a
dual cassette encoding an inducible Cas9 into the AAVS1 site of naïve hESC (iCas9). The …

Hematopoietic stem and progenitor cell (HSPC)-based ex vivo gene therapy has demonstrated
clinical success for X-linked severe combined immunodeficiency (SCID-X1) patients who …

Embryonic development is a continuum in vivo. Transcriptional analysis can separate
established human embryonic stem cells (hESC) into at least four distinct developmental …