The melanocortin-4 receptor (MC4R) is involved in energy homeostasis and is an important
drug target for syndromic obesity. We report the structure of the antagonist SHU9119-bound …

Ablation of hypothalamic AgRP (Agouti-related protein) neurons is known to lead to fatal
anorexia, whereas their activation stimulates voracious feeding and suppresses other …

Energy homeostasis is maintained by balancing energy intake and expenditure. Many signals
regulating energy intake are conserved between the human and teleost. However, before …

Zebrafish are an important model organism with inherent advantages that have the potential
to make zebrafish a widely applied model for the study of energy homeostasis and obesity. …

Mutations in the melanocortin‐4 receptor (MC4R) are the most common cause of early
syndromic obesity known. Most of these mutations result in a loss of protein expression, α‐…

… Author links open overlay panel Jacques Pantel a b , Savannah Y. Williams a , Dehui Mi b c
, Julien … Zhang, JP Kane, MJ Malloy, CR Pullinger, Y. Bromberg, LA Pennacchio, R. Dent, R. …

The melanocortin receptors (MC1R–MC5R) belong to class A G-protein-coupled receptors (GPCRs)
and are known to have receptor-specific roles in normal and diseased states. …

Melanocortin peptides containing a 3-(2-naphthyl)-d-alanine residue in position 7 (DNal(2′)
7 ), reported as melanocortin-3 receptor (MC3R) subtype-specific agonists in two separate …

… All tropical savannahs are experiencing extensive … to savannahs. Here, using a recently
published ecosystem intactness metric, we assess the current condition of tropical savannahs …

The melanocortin-3 receptor (MC3R) acts presynaptically to regulate GABA release from
agouti-related protein (AgRP) nerve terminals and thus may be a negative regulator of multiple …