Nonhuman primates were used to develop an animal model that closely mimics human
Mycobacterium tuberculosis infection. Cynomolgus macaques were infected with low doses of …

We previously described that low-dose Mycobacterium tuberculosis infection in cynomolgus
macaques results in a spectrum of disease similar to that of human infection: primary …

Infection with Asian-lineage Zika virus (ZIKV) has been associated with Guillain–Barré
syndrome and fetal abnormalities, but the underlying mechanisms remain poorly understood. …

Little is known regarding the early events of infection of humans with Mycobacterium tuberculosis.
The cynomolgus macaque is a useful model of tuberculosis, with strong similarities to …

Objective An increased risk of tuberculosis has been documented in humans treated with
tumor necrosis factor α (TNFα)–neutralizing agents. In murine models, impaired signaling by …

“Elite controllers” are individuals that durably control human immunodeficiency virus or
simian immunodeficiency virus replication without therapeutic intervention. The study of these …

Recent human decedent model studies 1 , 2 and compassionate xenograft use 3 have explored
the promise of porcine organs for human transplantation. To proceed to human studies, …

Somatic cell nuclear transfer (SCNT)(1) in nonhuman primates could accelerate medical
research by contributing identical animals for research and clarifying embryonic stem cell …

Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To
model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV …

In mouse models of influenza, T cells can confer broad protection against multiple viral
subtypes when antibodies raised against a single subtype fail to do so. However, the role of T …