Tumours evolve to cope with environmental stresses or challenges such as nutrient starvation,
depletion of survival factors, and unbalanced mechanical forces. The uncontrolled growth …

The Scar/WAVE complex drives actin nucleation during cell migration. Interestingly, the
same complex is important in forming membrane ruffles during macropinocytosis, a process …

Coenzyme A (CoA) is an essential cofactor present in all living cells. Under physiological
conditions, CoA mainly functions to generate metabolically active CoA thioesters, which are …

Rac1 is a major regulator of actin dynamics, with GTP-bound Rac1 promoting actin assembly
via the Scar/WAVE complex. CYRI competes with Scar/WAVE for interaction with Rac1 in a …

Pancreatic ductal adenocarcinoma carries a dismal prognosis, with high rates of metastasis
and few treatment options. Hyperactivation of KRAS in almost all tumours drives RAC1 …

Partial substitution of nitrate (NO 3 - ) with chloride (Cl - ) in the nutrient solution supplied to
tomato crops (beefsteak and cherry types), grown in a closed hydroponic system, maintained …

How cells breach basement membrane barriers remains an area of active research. In this
issue of Developmental Cell, Kelley et al. (2019) reveal that the C. elegans anchor cell uses …

In this study, we investigated the effect of individual and combined applications of
manganese (Mn) and zinc (Zn) chelates on common bean grown in hydroponics (nutrient film …

CYRI proteins promote lamellipodial dynamics by opposing Rac1-mediated activation of the
Scar/WAVE complex. This activity also supports resolution of macropinocytic cups, …

Controlled pulmonary drug delivery systems employing non-spherical particles as drug
carriers attract considerable attention nowadays. Such anisotropic morphologies may travel …