Background With approximately one-third of their genomes consisting of linear and circular
plasmids, the Lyme disease agent cluster of species has the most complex genomes among …

Background The bacterial genus Borrelia (phylum Spirochaetes) consists of two groups of
pathogens represented respectively by B. burgdorferi, the agent of Lyme borreliosis, and B. …

A mixed infection of a single tick or host by Lyme disease spirochetes is common and a
unique challenge for the diagnosis, treatment, and surveillance of Lyme disease. Here, we …

Genome sequences constitute the primary evidence on the origin and spread of the 2019-2020
Covid-19 pandemic. Rapid comparative analysis of coronavirus SARS-CoV-2 genomes …

Natural populations of pathogens and their hosts are engaged in an arms race in which the
pathogens diversify to escape host immunity while the hosts evolve novel immunity. This co-…

Background Automated bioinformatics workflows are more robust, easier to maintain, and
results more reproducible when built with command-line utilities than with custom-coded …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has accumulated genomic
mutations at an approximately linear rate since it first infected human populations in late …

VlsE (variable major protein-like sequence, expressed) is an outer surface protein of the Lyme
disease pathogen (Borreliella species) and a key diagnostic biomarker of Lyme disease. …

VlsE (variable major protein-like sequence, expressed) is an outer surface protein of the
Lyme disease pathogen (Borreliella species) responsible for its within-host antigenic variation …

Phylogenomic footprinting is an approach for ab initio identification of genome-wide regulatory
elements in bacterial species based on sequence conservation. The statistical power of …