The recognition of distinctly modified histones by specialized ‘effector’ proteins constitutes a
key mechanism for transducing molecular events at chromatin to biological outcomes 1 . …

Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength‐selective
illumination have been used to sequentially inactivate organismal gene function. The …

Heterobifunctional molecules have proven powerful tools to induce ligase-dependent
ubiquitination of target proteins. We describe here a chemical strategy for controlling a different …

The nucleotide-binding-domain (NBD)–and leucine-rich repeat (LRR)–containing (NLR)
family, pyrin-domain–containing 3 (NLRP3) inflammasome drives pathological inflammation in …

Genetic and non-genetic heterogeneity within cancer cell populations represent major
challenges to anticancer therapies. We currently lack robust methods to determine how …

Deciphering the molecular mechanisms that underlie embryogenesis requires an ability to
alter gene function with spatial and temporal precision. Synthetic reagents can be valuable …

Targeted degradation of proteins by chimeric heterobifunctional degraders has emerged as
a major drug discovery paradigm. Despite the increased interest in this approach, the criteria …

Basal constriction occurs at the zebrafish midbrain–hindbrain boundary constriction (MHBC)
and is likely a widespread morphogenetic mechanism. 3D reconstruction demonstrates that …

N-linked glycosylation is one of the most common and complex posttranslational modifications
that govern the biological functions and physicochemical properties of therapeutic …

T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic
for treatment of a variety of hematological and solid tumor indications. However, preclinical …