Fat-soluble ligands, including sex steroid hormones and environmental toxins, activate
ligand-dependent DNA-sequence-specific transcriptional factors that transduce signals through …

Androgens play pivotal roles in the regulation of male development and physiological
processes, particularly in the male reproductive system. Most biological effects of androgens are …

Epigenetic modifications at the histone level affect gene regulation in response to extracellular
signals 1 , 2 . However, regulated epigenetic modifications at the DNA level, especially …

Prostate cancer development is associated with hyperactive androgen signaling. However,
the molecular link between androgen receptor (AR) function and humoral factors remains …

Background Microelectrode array (MEA) systems are valuable for in vitro assessment of
neurotoxicity and drug efficiency. However, several difficulties such as protracted functional …

Next-generation sequencing technology may clarify microbiota that are as yet poorly
understood in the soil, the rhizosphere, and the phyllosphere of vineyards. To provide new …

The urachal carcinoma, in a 64-year-old male with multiple lung metastases, had shown the
resistance to several anti-neoplastic agents including cisplatinum, methotrexate, 5-FU, …

Objective To demonstrate the ability of the nCounter Analysis System, a nanowire technology,
to sensitively and accurately detect cancer-testis antigens (CTAs) in men with prostate …

Molecular targeted therapy using poly (ADP-ribose) polymerase inhibitors has improved
survival in patients with castration-resistant prostate cancer (CRPC). However, this approach is …

Prostate cancer is a heterogeneous disease and thus, it is important to understand whether
among the heterogeneous collection of cell types, androgen‐deprivation insensitive cells …