Metabolism is a vital cellular process, and its malfunction is a major contributor to human
disease. Metabolic networks are complex and highly interconnected, and thus systems-level …

The manner in which microorganisms utilize their metabolic processes can be predicted
using constraint-based analysis of genome-scale metabolic networks. Herein, we present the …

Reconstructions of cellular metabolism are publicly available for a variety of different
microorganisms and some mammalian genomes. To date, these reconstructions are “genome-scale…

Background Several strains of bacteria have sequenced and annotated genomes, which have
been used in conjunction with biochemical and physiological data to reconstruct genome-…

Controversies over diagnostic testing have dominated US headlines about severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus responsible for …

Coronavirus 3′-to-5′ exoribonuclease (ExoN), residing in the nonstructural protein (nsp)
10–nsp14 complex, boosts replication fidelity by proofreading RNA synthesis and is critical …

Epithelial-to-mesenchymal transition (EMT) has been closely linked with therapy resistance
and cancer stem cells (CSCs). However, EMT pathways have proven challenging to …

Gray wolves (Canis lupus) were extirpated from the northern Rocky Mountains (NRM) of the
United States by the 1930s. Dispersing wolves from Canada naturally recolonized Montana …

Medical screening and biological monitoring are two tech-niquesin a continuum of practices
used to prevent occupational disease. Medical screening is the examination of workers for …

Ischemia-reperfusion of the intestine produces a set of inflammatory mediators, the origin of
which has recently been shown to involve pancreatic digestive enzymes. Matrix …