A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

A fundamental challenge in mammalian biology has been the elucidation of mechanisms
linking DNA methylation and histone post-translational modifications. Human UHRF1 (ubiquitin…

Polycomb repressive complex 2 (PRC2) regulates pluripotency, differentiation, and
tumorigenesis through catalysis of histone H3 lysine 27 trimethylation (H3K27me3) on chromatin. …

DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development 1 , 2 . Dysregulation of this …

Histone post-translational modifications regulate chromatin structure and function largely
through interactions with effector proteins that often contain multiple histone-binding domains. …

DNA methylation generally functions as a repressive transcriptional signal, but it is also
known to activate gene expression. In either case, the downstream factors remain largely …

How epigenetic information is transmitted from generation to generation remains largely
unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-…

Access to high-quality antibodies is a necessity for the study of histones and their posttranslational
modifications (PTMs). Here we debut the Histone Antibody Specificity Database (http://…

Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β-…

Pemetrexed represents the first antifolate cancer drug to be approved by the Food and Drug
Administration in 20 years; it is currently in widespread use for first line therapy of …