User profiles for Scott E. Williams

Scott E Williams

Assistant Professor of Pathology & Laboratory Medicine, University of North Carolina at …
Verified email at med.unc.edu
Cited by 3494

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

SE Williams, S Beronja, HA Pasolli, E Fuchs - Nature, 2011 - nature.com
Stem and progenitor cells use asymmetric cell divisions to balance proliferation and
differentiation. Evidence from invertebrates shows that this process is regulated by proteins …

[PDF][PDF] Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm

SE Williams, F Mann, L Erskine, T Sakurai, S Wei… - Neuron, 2003 - cell.com
In animals with binocular vision, retinal ganglion cell (RGC) axons either cross or avoid the
midline at the optic chiasm. Here, we show that ephrin-Bs in the chiasm region direct the …

[HTML][HTML] A role for the primary cilium in Notch signaling and epidermal differentiation during skin development

…, N Stokes, S Chai, AS Shah, SE Williams, E Fuchs - Cell, 2011 - cell.com
Ciliogenesis precedes lineage-determining signaling in skin development. To understand
why, we performed shRNA-mediated knockdown of seven intraflagellar transport proteins (…

Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits

L Erskine, SE Williams, K Brose, T Kidd… - Journal of …, 2000 - Soc Neuroscience
The ventral midline of the nervous system is an important choice point at which growing axons
decide whether to cross and project contralaterally or remain on the same side of the brain…

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation

…, H Amalia Pasolli, SE Williams, E Fuchs - Nature cell …, 2011 - nature.com
During development, a polarized epidermal sheet undergoes stratification and differentiation
to produce the skin barrier. Through mechanisms that are poorly understood, the process …

Effects of DL-malate on ruminal metabolism and performance of cattle fed a high-concentrate diet

…, DJ Nisbet, GM Hill, SE Williams - Journal of animal …, 1999 - academic.oup.com
To determine the effects of DL-malate on ruminal metabolism, four steers equipped with
ruminal cannulas were fed an 80% rolled grain (75% corn:25% wheat) diet twice daily with a …

Par3–mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN

SE Williams, LA Ratliff, MP Postiglione, JA Knoblich… - Nature cell …, 2014 - nature.com
Asymmetric cell divisions allow stem cells to balance proliferation and differentiation. During
embryogenesis, murine epidermis expands rapidly from a single layer of unspecified basal …

Oriented divisions, fate decisions

SE Williams, E Fuchs - Current opinion in cell biology, 2013 - Elsevier
During development, the establishment of proper tissue architecture depends upon the
coordinated control of cell divisions not only in space and time, but also direction. Execution of an …

Molecular subtype-specific immunocompetent models of high-grade urothelial carcinoma reveal differential neoantigen expression and response to immunotherapy

…, U Manocha, KM Byrd, JS Damrauer, SE Williams… - Cancer research, 2018 - AACR
High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit differences in
underlying tumor biology and can be divided into luminal-like and basal-like subtypes. We …

Foxd1 is required for proper formation of the optic chiasm

E Herrera, R Marcus, S Li, SE Williams, L Erskine, E Lai… - 2004 - journals.biologists.com
In animals with binocular vision, retinal ganglion cell (RGC) axons from each eye sort in the
developing ventral diencephalon to project to ipsi- or contralateral targets, thereby forming …