Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

…, PC Trampont, ER Lazarowski, A Kadl, SF Walk… - Nature, 2009 - nature.com
Phagocytic removal of apoptotic cells occurs efficiently in vivo such that even in tissues with
significant apoptosis, very few apoptotic cells are detectable 1 . This is thought to be due to …

Pannexin 1 channels mediate 'find-me'signal release and membrane permeability during apoptosis

FB Chekeni, MR Elliott, JK Sandilos, SF Walk… - Nature, 2010 - nature.com
Apoptotic cells release ‘find-me’ signals at the earliest stages of death to recruit phagocytes
1 . The nucleotides ATP and UTP represent one class of find-me signals 2 , but their …

Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex

E Brugnera, L Haney, C Grimsley, M Lu, SF Walk… - Nature cell …, 2002 - nature.com
Mammalian Dock180 and ELMO proteins, and their homologues in Caenorhabditis elegans
and Drosophila melanogaster, function as critical upstream regulators of Rac during …

[HTML][HTML] CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

…, JM Kinchen, LB Haney, K Nishiwaki, SF Walk… - Cell, 2001 - cell.com
The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII,
dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells …

[HTML][HTML] Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region*♦

…, YH Chiu, FB Chekeni, AJ Armstrong, SF Walk… - Journal of Biological …, 2012 - ASBMB
Pannexin 1 (PANX1) channels mediate release of ATP, a "find-me" signal that recruits
macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase-mediated …

Metabolites released from apoptotic cells act as tissue messengers

…, JSA Perry, Y Guo, S Morioka, B Barron, SF Walk… - Nature, 2020 - nature.com
Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body 1 , and regulates inflammation, cell proliferation, and tissue regeneration 2 , 3 – …

Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo

…, MM Zhou, JC Pratt, JE Harlan, SF Walk… - … and Cellular Biology, 1997 - Am Soc Microbiol
The adapter protein Shc is a critical component of mitogenic signaling pathways initiated by
a number of receptors. Shc can directly bind to several tyrosine-phosphorylated receptors …

[HTML][HTML] Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivorequires the Shc-phosphotyrosine binding domain and two specific …

TD Lamkin, SF Walk, L Liu, JE Damen, G Krystal… - Journal of Biological …, 1997 - ASBMB
The adapter protein Shc has been implicated in mitogenic signaling via growth factor
receptors, cytokine receptors, and antigen receptors on lymphocytes. Besides the well …

[HTML][HTML] ELMO1 signaling is a promoter of osteoclast function and bone loss

…, JSA Perry, M Zhou, A Ceroi, I Smirnov, SF Walk… - Nature …, 2021 - nature.com
Osteoporosis affects millions worldwide and is often caused by osteoclast induced bone loss.
Here, we identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ in …

Expression of the subtype 1A dopamine receptor in the rat heart

…, DP O'Connell, C Vaughan, SJ Botkin, SF Walk… - …, 1996 - Am Heart Assoc
The subtype 1A dopamine receptor (D 1A ) has recently been detected in the rat kidney. In
the present study using light microscopic immunohistochemistry, electron microscopic …