Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
…, PC Trampont, ER Lazarowski, A Kadl, SF Walk… - Nature, 2009 - nature.com
Phagocytic removal of apoptotic cells occurs efficiently in vivo such that even in tissues with
significant apoptosis, very few apoptotic cells are detectable 1 . This is thought to be due to …
significant apoptosis, very few apoptotic cells are detectable 1 . This is thought to be due to …
Pannexin 1 channels mediate 'find-me'signal release and membrane permeability during apoptosis
FB Chekeni, MR Elliott, JK Sandilos, SF Walk… - Nature, 2010 - nature.com
Apoptotic cells release ‘find-me’ signals at the earliest stages of death to recruit phagocytes
1 . The nucleotides ATP and UTP represent one class of find-me signals 2 , but their …
1 . The nucleotides ATP and UTP represent one class of find-me signals 2 , but their …
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
E Brugnera, L Haney, C Grimsley, M Lu, SF Walk… - Nature cell …, 2002 - nature.com
Mammalian Dock180 and ELMO proteins, and their homologues in Caenorhabditis elegans
and Drosophila melanogaster, function as critical upstream regulators of Rac during …
and Drosophila melanogaster, function as critical upstream regulators of Rac during …
[HTML][HTML] CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration
…, JM Kinchen, LB Haney, K Nishiwaki, SF Walk… - Cell, 2001 - cell.com
The C. elegans genes ced-2, ced-5, and ced-10, and their mammalian homologs crkII,
dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells …
dock180, and rac1, mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells …
[HTML][HTML] Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region*♦
…, YH Chiu, FB Chekeni, AJ Armstrong, SF Walk… - Journal of Biological …, 2012 - ASBMB
Pannexin 1 (PANX1) channels mediate release of ATP, a "find-me" signal that recruits
macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase-mediated …
macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase-mediated …
Metabolites released from apoptotic cells act as tissue messengers
Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body 1 , and regulates inflammation, cell proliferation, and tissue regeneration 2 , 3 – …
in the body 1 , and regulates inflammation, cell proliferation, and tissue regeneration 2 , 3 – …
Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo
…, MM Zhou, JC Pratt, JE Harlan, SF Walk… - … and Cellular Biology, 1997 - Am Soc Microbiol
The adapter protein Shc is a critical component of mitogenic signaling pathways initiated by
a number of receptors. Shc can directly bind to several tyrosine-phosphorylated receptors …
a number of receptors. Shc can directly bind to several tyrosine-phosphorylated receptors …
[HTML][HTML] Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivorequires the Shc-phosphotyrosine binding domain and two specific …
TD Lamkin, SF Walk, L Liu, JE Damen, G Krystal… - Journal of Biological …, 1997 - ASBMB
The adapter protein Shc has been implicated in mitogenic signaling via growth factor
receptors, cytokine receptors, and antigen receptors on lymphocytes. Besides the well …
receptors, cytokine receptors, and antigen receptors on lymphocytes. Besides the well …
[HTML][HTML] ELMO1 signaling is a promoter of osteoclast function and bone loss
Osteoporosis affects millions worldwide and is often caused by osteoclast induced bone loss.
Here, we identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ in …
Here, we identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ in …
Expression of the subtype 1A dopamine receptor in the rat heart
…, DP O'Connell, C Vaughan, SJ Botkin, SF Walk… - …, 1996 - Am Heart Assoc
The subtype 1A dopamine receptor (D 1A ) has recently been detected in the rat kidney. In
the present study using light microscopic immunohistochemistry, electron microscopic …
the present study using light microscopic immunohistochemistry, electron microscopic …