We have adapted a bacterial CRISPR RNA/Cas9 system to precisely engineer the Drosophila
genome and report that Cas9-mediated genomic modifications are efficiently transmitted …

We and others recently demonstrated that the readily programmable CRISPR/Cas9 system
can be used to edit the Drosophila genome. However, most applications to date have relied …

Gene drive systems promote the spread of genetic elements through populations by assuring
they are inherited more often than Mendelian segregation would predict (see the figure). …

The CRISPR‐Cas9 system has transformed genome engineering of model organisms from
possible to practical. CRISPR‐Cas9 can be readily programmed to generate sequence‐…

The CRISPR/Cas9 system has attracted significant attention for its potential to transform
genome engineering. We and others have recently shown that the RNA-guided Cas9 nuclease …

Neurons communicate through Ca 2+ -dependent neurotransmitter release at presynaptic
active zones (AZs). Neurotransmitter release properties play a key role in defining information …

The readily programmable CRISPR-Cas9 system is transforming genome engineering. We
and others have adapted the S. pyogenes CRISPR-Cas9 system to precisely engineer the …

The strength of synaptic connections varies significantly and is a key determinant of
communication within neural circuits. Mechanistic insight into presynaptic factors that establish and …

Neuronal communication depends on the precisely orchestrated release of neurotransmitter
at specialized sites called active zones (AZs). A small number of scaffolding and …

Synapses are highly specialized for neurotransmitter signaling, yet activity-dependent
growth factor release also plays critical roles at synapses. While efficient neurotransmitter …