User profiles for Scott Keeney
Scott KeeneyHoward Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center Verified email at ski.mskcc.org Cited by 18918 |
Spo11 and the formation of DNA double-strand breaks in meiosis
S Keeney - Recombination and meiosis: crossing-over and …, 2007 - Springer
Meiotic recombination is carried out through a specialized pathway for the formation and
repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal …
repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal …
Mechanism and control of meiotic recombination initiation
S Keeney - 2001 - Elsevier
Homologous recombination is essential during meiosis in most sexually reproducing
organisms. In budding yeast, and most likely in other organisms as well, meiotic recombination …
organisms. In budding yeast, and most likely in other organisms as well, meiotic recombination …
[HTML][HTML] Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family
S Keeney, CN Giroux, N Kleckner - Cell, 1997 - cell.com
Meiotic recombination in S. cerevisiae is initiated by double-strand breaks (DSBs). In certain
mutants, breaks accumulate with a covalently attached protein, suggesting that cleavage is …
mutants, breaks accumulate with a covalently attached protein, suggesting that cleavage is …
Mechanism and regulation of meiotic recombination initiation
I Lam, S Keeney - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Meiotic recombination involves the formation and repair of programmed DNA double-strand
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …
Computed structures of core eukaryotic protein complexes
INTRODUCTION Protein-protein interactions play critical roles in biology, but the structures
of many eukaryotic protein complexes are unknown, and there are likely many interactions …
of many eukaryotic protein complexes are unknown, and there are likely many interactions …
Recombinational DNA double-strand breaks in mice precede synapsis
In Saccharomyces cerevisiae, meiotic recombination is initiated by Spo11-dependent
double-strand breaks (DSBs), a process that precedes homologous synapsis. Here we use an …
double-strand breaks (DSBs), a process that precedes homologous synapsis. Here we use an …
[PDF][PDF] Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11
F Baudat, K Manova, JP Yuen, M Jasin, S Keeney - Molecular cell, 2000 - cell.com
Spo11, a protein first identified in yeast, is thought to generate the chromosome breaks that
initiate meiotic recombination. We now report that disruption of mouse Spo11 leads to severe …
initiate meiotic recombination. We now report that disruption of mouse Spo11 leads to severe …
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks
DNA double-strand breaks (DSBs) with protein covalently attached to 5′ strand termini are
formed by Spo11 to initiate meiotic recombination 1 , 2 . The Spo11 protein must be …
formed by Spo11 to initiate meiotic recombination 1 , 2 . The Spo11 protein must be …
[HTML][HTML] A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation
The nonrandom distribution of meiotic recombination influences patterns of inheritance and
genome evolution, but chromosomal features governing this distribution are poorly …
genome evolution, but chromosomal features governing this distribution are poorly …
Clarifying the mechanics of DNA strand exchange in meiotic recombination
During meiosis, accurate separation of maternal and paternal chromosomes requires that
they first be connected to one another through homologous recombination. Meiotic …
they first be connected to one another through homologous recombination. Meiotic …