R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation
…, E Herlaar, A Lau, C Young, BR Wong, S Lovell… - … of Pharmacology and …, 2006 - ASPET
Recent compelling evidence has lead to renewed interest in the role of antibodies and
immune complexes in the pathogenesis of several autoimmune disorders, such as rheumatoid …
immune complexes in the pathogenesis of several autoimmune disorders, such as rheumatoid …
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice
…, MM Kashipathy, KP Battaile, S Lovell… - Science translational …, 2020 - science.org
Pathogenic coronaviruses are a major threat to global public health, as exemplified by severe
acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome …
acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome …
Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19
Two proteases produced by the SARS-CoV-2 virus, the main protease and papain-like
protease, are essential for viral replication and have become the focus of drug development …
protease, are essential for viral replication and have become the focus of drug development …
Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses
Phylogenetic analysis has demonstrated that some positive-sense RNA viruses can be
classified into the picornavirus-like supercluster, which includes picornaviruses, caliciviruses, …
classified into the picornavirus-like supercluster, which includes picornaviruses, caliciviruses, …
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124
DS Auld, S Lovell, N Thorne, WA Lea… - Proceedings of the …, 2010 - National Acad Sciences
Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly
used in chemical biology and drug discovery assays. PTC124 (Ataluren; (3-[5-(2-fluorophenyl)-1,…
used in chemical biology and drug discovery assays. PTC124 (Ataluren; (3-[5-(2-fluorophenyl)-1,…
[HTML][HTML] The Min oscillator uses MinD-dependent conformational changes in MinE to spatially regulate cytokinesis
In E. coli, MinD recruits MinE to the membrane, leading to a coupled oscillation required for
spatial regulation of the cytokinetic Z ring. How these proteins interact, however, is not clear …
spatial regulation of the cytokinetic Z ring. How these proteins interact, however, is not clear …
[PDF][PDF] Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter
N Thorne, M Shen, WA Lea, A Simeonov, S Lovell… - Chemistry & biology, 2012 - cell.com
Firefly luciferase (FLuc) is frequently used as a reporter in high-throughput screening assays,
owing to the exceptional sensitivity, dynamic range, and rapid measurement that …
owing to the exceptional sensitivity, dynamic range, and rapid measurement that …
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
…, MM Kashipathy, KP Battaile, S Lovell… - Proceedings of the …, 2021 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a
serious global public health threat. The 3C-like protease (3CLpro) is a virus protease …
serious global public health threat. The 3C-like protease (3CLpro) is a virus protease …
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
There are currently no approved vaccines or small molecule therapeutics available for the
prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) …
prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) …
Identification of highly selective covalent inhibitors by phage display
Molecules that covalently bind macromolecular targets have found widespread applications
as activity-based probes and as irreversibly binding drugs. However, the general reactivity …
as activity-based probes and as irreversibly binding drugs. However, the general reactivity …