Africa is the source of all modern humans, but characterization of genetic variation and of
relationships among populations across the continent has been enigmatic. We studied 121 …

The majority of studies of genetic association with disease have been performed in Europeans.
This European bias has important implications for risk prediction of diseases across …

The frequencies of low-activity alleles of glucose-6-phosphate dehydrogenase in humans
are highly correlated with the prevalence of malaria. These “deficiency” alleles are thought to …

Motivation: The sequencing of the human genome has made it possible to identify an informative
set of >1 million single nucleotide polymorphisms (SNPs) across the genome that can …

Multifactor dimensionality reduction (MDR) was developed as a method for detecting statistical
patterns of epistasis. The overall goal of MDR is to change the representation space of …

Africa is one of the most ethnically and genetically diverse regions of the world. It is thought
to be the ancestral homeland of all modern humans, and is the homeland of millions of …

Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD)
provides a way of localizing genes that cause disease, in admixed ethnic groups such as …

Essential hypertension is a common disease that has complex multifactorial etiology. For this
reason, it is not surprising that studies of the effects of single genes on hypertension have …

The widespread availability of high-throughput genotyping technology has opened the door
to the era of personal genetics, which brings to consumers the promise of using genetic …

Epistasis plays an important role in the genetic architecture of common human diseases
and can be viewed from two perspectives, biological and statistical, each derived from and …