Mitotic entry and exit are switch‐like transitions that are driven by the activation and
inactivation of Cdk1 and mitotic cyclins. This simple on/off reaction turns out to be a complex …

The abrupt and irreversible transition from interphase to M phase is essential to separate
DNA replication from chromosome segregation. This transition requires the switch-like …

Distinct protein phosphorylation levels in interphase and M phase require tight regulation of
Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop, …

Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subunit
by separase triggers chromosome segregation in anaphase. Vertebrate separase is held …

The transitions between phases of the cell cycle have evolved to be robust and switch-like,
which ensures temporal separation of DNA replication, sister chromatid separation, and cell …

Antisense transcription is widespread in genomes. Despite large differences in gene size and
architecture, we find that yeast and human genes share a unique, antisense transcription‐…

We present a comprehensive resource of 257 kinase inhibitor profiles against 365 human
protein kinases using gold-standard kinase activity assays. We show the utility of this dataset …

Antiangiogenic therapy began as an effort to inhibit VEGF signaling, which was thought to
be the sole factor driving tumor angiogenesis. It has become clear that there are more pro-…

Nearly all tissues require vascularization to maintain homeostasis. Angiogenesis, or the
formation of new microvasculature from existing vessels, allows for tissue growth in both normal …

The mitotic cell cycle is fundamental to eukaryotic life. In mitosis, replicated chromosomes
are segregated to form two new nuclei. This is essential to ensure the maintenance of …