The 4D organization of the interphase nucleus, or the 4D Nucleome (4DN), reflects a dynamical
interaction between 3D genome structure and function and its relationship to phenotype. …

Increased adipose tissue macrophages (ATMs) correlate with metabolic dysfunction in
humans and are causal in development of insulin resistance in mice. Recent bulk and single-cell …

The day we understand the time evolution of subcellular events at a level of detail comparable
to physical systems governed by Newton’s laws of motion seems far away. Even so, …

… Scott Ronquist; Scott Ronquist … Oakes, Scott Ronquist, Haiming Chen, Indika
Rajapakse, Max S. Wicha, Jacqueline S. Jeruss, Lonnie D. …

Chromosomal aneuploidy is a defining feature of carcinomas and results in tumor-entity
specific genomic imbalances. For instance, most sporadic colorectal carcinomas carry extra …

Deciphering the non-trivial interactions and mechanisms driving the evolution of time-varying
complex networks (TVCNs) plays a crucial role in designing optimal control strategies for …

Genome architecture has emerged as a critical element of transcriptional regulation, although
its role in the control of cell identity is not well understood. Here we use transcription factor …

Data on genome organization and output over time, or the 4D Nucleome (4DN), require
synthesis for meaningful interpretation. Development of tools for the efficient integration of these …

Every human somatic cell inherits a maternal and a paternal genome, which work together
to give rise to cellular phenotypes. However, the allele-specific relationship between gene …

Canonical Wnt signaling is crucial for intestinal homeostasis as TCF4, the major Wnt signaling
effector in the intestines, is required for stem cell maintenance. The capability of TCF4 to …