The cell tropism of human noroviruses and the development of an in vitro infection model
remain elusive. Although susceptibility to individual human norovirus strains correlates with an …

Human noroviruses (HuNoVs) are a leading cause of foodborne disease and severe childhood
diarrhea, and they cause a majority of the gastroenteritis outbreaks worldwide. However, …

Despite active immune responses, gammaherpesviruses establish latency. In a related
process, these viruses also persistently replicate by using a mechanism that requires different …

Gammaherpesviruses such as Epstein-Barr virus and Kaposi's sarcoma-associated
herpesvirus are important human pathogens that establish long-term latent infections. …

Upon viral infection, the mitochondrial antiviral signaling (MAVS)-IKKβ pathway is activated
to restrict viral replication. Manipulation of immune signaling events by pathogens has been …

Establishment of latent infection and reactivation from latency are critical aspects of herpesvirus
infection and pathogenesis. Interfering with either of these steps in the herpesvirus life …

Regulation of T cell activation requires two signals. First, appropriately presented Ag in the
context of MHC interacts with the T cell Ag receptor-CD3 complex. The best-studied second …

Our appreciation for the extent of Epstein Barr virus (EBV) transcriptome complexity continues
to grow through findings of EBV encoded microRNAs, new long non-coding RNAs as well …

Gammaherpesviruses are an important class of oncogenic pathogens that are exquisitely
evolved to their respective hosts. As such, the human gammaherpesviruses Epstein-Barr virus (…

Human gammaherpesvirus infections are associated with development of lymphoproliferative
disease. Understanding of the mechanisms of gammaherpesvirus lymphomagenesis …