Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

Behaviors and disorders related to self-regulation, such as substance use, antisocial behavior
and attention-deficit/hyperactivity disorder, are collectively referred to as externalizing and …

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

We report results from a genome wide association study (GWAS) of five quantitative indicators
of behavioral disinhibition: nicotine, alcohol consumption, alcohol dependence, illicit drugs…

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

Genotype imputation is a key component of genetic association studies, where it increases
power, facilitates meta-analysis, and aids interpretation of signals. Genotype imputation is …

Behavioral disinhibition is a trait hypothesized to represent a general vulnerability to the
development of substance use disorders. We used a large community-representative sample (N …

This article reviews the Akaike information criterion (AIC) and the Bayesian information criterion
(BIC) in model selection and the appraisal of psychological theory. The focus is on latent …

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …

Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic
variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We …