Despite accumulating evidence suggesting local self-maintenance of tissue macrophages
in the steady state, the dogma remains that tissue macrophages derive from monocytes. …

While it is clear that a single hematopoietic stem cell (HSC) is capable of giving rise to all
other hematopoietic cell types, the differentiation paths beyond HSC remain controversial. …

The generation of distinct hematopoietic cell types, including tissue-resident immune cells,
distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying …

Hematopoiesis is arguably one of the best understood stem cell systems; however,
significant challenges remain to reach a consensus understanding of the lineage potential, …

Defining differentiation pathways is central to understanding the pathogenesis of hematopoietic
disorders, including leukemia. The function of the receptor tyrosine kinase Flk2 (Flt3) in …

Genetic fate-mapping approaches provide a unique opportunity to assess differentiation
pathways under physiological conditions. We have recently employed a lineage tracing …

Highlights • We report the generation of a new transgenic mouse (“Vav-GFP”) with
hematopoietic-specific green fluorescent protein (GFP) expression. • There was no off-target …

We investigated the physical role of the extracellular matrix (ECM) in vascular homeostasis
in the basal chordate Botryllus schlosseri, which has a large, transparent, extracorporeal …

Hematopoietic stem cell (HSC) multipotency and self-renewal are typically defined through
serial transplantation experiments. Host conditioning is necessary for robust HSC engraftment…

Hematopoietic stem and progenitor cell (HSPC) transplantation is the paradigm for stem cell
therapies. The protocol described here enables quantitative assessment of the body-wide …