Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a Burkholderia bacterium

SB Romanowski, S Lee, S Kunakom… - Proceedings of the …, 2023 - National Acad Sciences
Bacterial natural products have found many important industrial applications. Yet traditional
discovery pipelines often prioritize individual natural product families despite the presence of …

Understanding Autologous Spliceostatin Transcriptional Regulation to Derive Parts for Heterologous Expression in a Burkholderia Bacterial Host

BI Adaikpoh, SB Romanowski… - ACS Synthetic …, 2023 - ACS Publications
Burkholderia β-Proteobacteria are emerging sources of natural products. We are interested
in developing Burkholderia sp. FERM BP-3421 into a synthetic biology chassis to facilitate …

Relationship between bacterial phylotype and specialized metabolite production in the culturable microbiome of two freshwater sponges

…, J Fitz-Henley, E Li, SB Romanowski… - ISME …, 2022 - academic.oup.com
Microbial drug discovery programs rely heavily on accessing bacterial diversity from the
environment to acquire new specialized metabolite (SM) lead compounds for the therapeutic …

Anal intraepithelial neoplasia: review and recommendations for screening and management

…, AE Singh, B Romanowski - International journal of …, 2013 - journals.sagepub.com
Anal cancer is a rare malignancy of the distal gastrointestinal tract, often associated with
human papillomavirus, the most common sexually transmitted infection worldwide. Currently …

An Enzyme Containing the Conserved Domain of Unknown Function DUF62 Acts as a Stereoselective (Rs,Sc)‐S‐Adenosylmethionine Hydrolase

T Kornfuehrer, S Romanowski… - …, 2020 - Wiley Online Library
Homochirality is a signature of biological systems. The essential and ubiquitous cofactor S‐adenosyl‐l‐methionine
(SAM) is synthesized in cells from adenosine triphosphate and l‐…

[HTML][HTML] Sensitivity and specificity of two investigational Point of care tests for Syphilis and HIV (PoSH Study) for the diagnosis and treatment of infectious syphilis in …

AE Singh, N Ives, J Gratrix, C Vetland, L Ferron… - Clinical Microbiology …, 2023 - Elsevier
Objectives Single-visit testing and treatment for syphilis can reduce follow-up visits. The
objectives of this study were to evaluate the performance and treatment outcomes of two dual …

Synthetic biology for natural product drug production and engineering

S Romanowski, AS Eustáquio - Current Opinion in Chemical Biology, 2020 - Elsevier
Natural products continue to provide privileged scaffolds for drug discovery. However, challenges
in supply and structure diversification can limit development. Here, we discuss recent (…

Establishing ABET accreditation criteria for data science

…, P Leidig, S Murray, RK Raj, CJ Romanowski - Proceedings of the …, 2021 - dl.acm.org
Prompted by the skyrocketing demand for data scientists, progress made by the ACM Data
Science Task Force on defining data science competencies, and inquiries about data science …

Theoretical limits of spatial resolution in elliptical‐centric contrast‐enhanced 3D‐MRA

SB Fain, SJ Riederer, MA Bernstein… - … in Medicine: An …, 1999 - Wiley Online Library
The point spread function (PSF) for contrast‐enhanced three‐dimensional (3D) MR
angiography using the elliptical centric view order is derived. This view order has been shown …

An initial exploration of visual cues in head-mounted display augmented reality for book searching

Y Zhang, A Nowak, A Romanowski… - Proceedings of the 21st …, 2022 - dl.acm.org
Augmented reality (AR) is today becoming more widely utilized as it allows for interacting
with the virtual objects. In this study, we propose an head-mounted display (HMD) AR system …