DNA damage can stall the DNA replication machinery, leading to genomic instability. Thus,
numerous mechanisms exist to complete genome duplication in the absence of a pristine …

The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available
against acute myelogenous leukemia (AML). Together with anthracyclines, ara-C forms the …

PrimPol is a recently identified polymerase involved in eukaryotic DNA damage tolerance,
employed in both re-priming and translesion synthesis mechanisms to bypass nuclear and …

Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs that,
starting from the small field of paediatric oncology, in combination with other …

With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of
nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-…

Recently, we demonstrated that sterile α motif and HD domain containing protein 1 (SAMHD1)
is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity of …

The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is
an important anticancer strategy. The replication and repair of DNA are dependent upon the …

Artificially modified nucleotides, in the form of nucleoside analogues, are widely used in the
treatment of cancers and various other diseases, and have become important tools in the …

The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute
myeloid leukaemia ( AML ) as well as other haematological and lymphoid malignancies, but …

Faithful copying of the genome is essential for life. In eukaryotes, a single archaeo-eukaryotic
primase (AEP), DNA primase, is required for the initiation and progression of DNA …