Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis
provides a model for understanding mammalian stem cells and their niches, but the …

Breast cancer is the most common malignancy in United States women, accounting for >40,000
deaths each year. These breast tumors are comprised of phenotypically diverse …

A central issue in stem cell biology is to understand the mechanisms that regulate the self-renewal
of haematopoietic stem cells (HSCs), which are required for haematopoiesis to persist …

Recent advances have highlighted extensive phenotypic and functional similarities between
normal stem cells and cancer stem cells. This raises the question of whether disease …

To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in
vivo, we compared the gene expression profiles of highly purified HSCs and non-self-renewing …

Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic
system has given way to the prospective isolation of several tissue-specific stem and …

Solid cancer cells commonly enter the blood and disseminate systemically, but are highly
inefficient at forming distant metastases for poorly understood reasons. Here we studied …

Mammalian aging is associated with reduced tissue regeneration, increased degenerative
disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the …

Phenotypic and functional heterogeneity arise among cancer cells within the same tumour
as a consequence of genetic change, environmental differences and reversible changes in …

Listen to an interview with Sean Morrison on the stem cells podcast Much has been made of
the idea that asymmetric cell division is a defining characteristic of stem cells that enables …