Tumor molecular profiling is a fundamental component of precision oncology, enabling the
identification of genomic alterations in genes and pathways that can be targeted …

Background Risk stratification and therapeutic decision-making for myelodysplastic
syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS-R), …

Background B-cell maturation antigen (BCMA)–directed chimeric antigen receptor (CAR) T-cell
therapies have generated responses in patients with advanced myeloma, but relapses …

Acquired mutations are pervasive across normal tissues. However, understanding of the
processes that drive transformation of certain clones to cancer is limited. Here we study this …

The relationship between intestinal microbiota composition and acute graft-versus-host disease
(GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. …

Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has led to unprecedented responses
in patients with high-risk hematologic malignancies. However, up to 60% of patients still …

Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated
genes, commonly occurs among aging human hematopoietic stem cells. We analyzed …

Background Relationships between microbiota composition and clinical outcomes after
allogeneic hematopoietic-cell transplantation have been described in single-center studies. …

Intestinal bacteria may modulate the risk of infection and graft-versus-host disease (GVHD)
after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT recipients …

Tumor protein p53 (TP53) is the most frequently mutated gene in cancer 1 , 2 . In patients with
myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease …