The heart is formed from cardiogenic progenitors expressing the transcription factors Nkx2-5
and Isl1 (refs 1 and 2 ). These multipotent progenitors give rise to cardiomyocyte, smooth …

We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …

Despite recent advances in delineating the mechanisms involved in cardiogenesis, cellular
lineage specification remains incompletely understood. To explore the relationship between …

The discovery of methods to convert somatic cells into induced pluripotent stem cells (iPSCs)
through expression of a small combination of transcription factors has raised the possibility …

Tyrosine kinase inhibitors (TKIs), despite their efficacy as anticancer therapeutics, are
associated with cardiovascular side effects ranging from induced arrhythmias to heart failure. We …

Purpose of Review Coronavirus disease of 2019 (COVID-19) is a cause of significant
morbidity and mortality worldwide. While cardiac injury has been demonstrated in critically ill …

Background— Drug-induced arrhythmia is one of the most common causes of drug
development failure and withdrawal from market. This study tested whether human induced …

Rationale: Direct reprogramming of fibroblasts into cardiomyocytes is a novel strategy for
cardiac regeneration. However, the key determinants involved in this process are unknown. …

Background: Endothelial cells (ECs) display considerable functional heterogeneity depending
on the vessel and tissue in which they are located. Whereas these functional differences …

… We thank members of the Sean Wu lab for manuscript critique and Andrew Olson at the
Stanford Neuroscience Imaging Core Facility for assistance with confocal imaging. …