Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of
schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an …

Cooperation between DNA, RNA and protein regulates gene expression and controls
differentiation through interactions that connect regions of nucleic acids and protein domains and …

Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as potential …

Highly selective positive allosteric modulators (PAMs) of the M 1 subtype of muscarinic
acetylcholine receptor have emerged as an exciting new approach for improving cognitive …

A genetically valid animal model could transform our understanding of schizophrenia (SCZ)
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A, …

Selective activation of the M 1 subtype of muscarinic acetylcholine receptor, via positive
allosteric modulation (PAM), is an exciting strategy to improve cognition in schizophrenia and …

Abnormalities in the signaling of the N-methyl-d-aspartate subtype of the glutamate receptor
(NMDAR) within cortical and limbic brain regions are thought to underlie many of the …

Chronic liver injury causes fibrosis, characterized by the formation of scar tissue resulting
from excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cell (HSC) …

Background The prefrontal cortex (PFC) integrates information from multiple inputs to exert
top-down control allowing for appropriate responses in a given context. In psychiatric …

Although the most notable clinical symptoms of Huntington’s disease (HD) are motor
disturbances and brain atrophy, other symptoms include cognitive dysfunction, emotional and …