Pfam, available via servers in the UK ( http://pfam.sanger.ac.uk/ ) and the USA ( http://pfam.janelia.org/
), is a widely used database of protein families, containing 14 831 manually …

Probabilistic models are becoming increasingly important in analysing the huge amount of
data being produced by large-scale DNA-sequencing efforts such as the Human Genome …

We describe a program, tRNAscan-SE, which identifies 99–100% of transfer RNA genes in
DNA sequence while giving less than one false positive per 15 gigabases. Two previously …

In the last two years the Pfam database ( http://pfam.xfam.org ) has undergone a substantial
reorganisation to reduce the effort involved in making a release, thereby permitting more …

HMMER is a software suite for protein sequence similarity searches using probabilistic
methods. Previously, HMMER has mainly been available only as a computationally intensive …

The recent literature on profile hidden Markov model (profile HMM) methods and software is
reviewed. Profile HMMs turn a multiple sequence alignment into a position-specific scoring …

Pfam is a large collection of protein families and domains. Over the past 2 years the number
of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology …

The last few years have witnessed significant changes in Pfam ( https://pfam.xfam.org ). The
number of families has grown substantially to a total of 17,929 in release 32.0. New …

Profile hidden Markov models (profile HMMs) and probabilistic inference methods have made
important contributions to the theory of sequence database homology search. However, …

Pfam is a widely used database of protein families, currently containing more than 13 000
manually curated protein families as of release 26.0. Pfam is available via servers in the UK ( …