Burkholderia multivorans is an opportunistic pathogen capable of causing severe disease
in patients with cystic fibrosis (CF). Patients may be chronically infected for years, during …

Genome duplications are important evolutionary events that impact the rate and spectrum of
beneficial mutations and thus the rate of adaptation. Laboratory evolution experiments …

Beneficial mutations are the driving force of adaptive evolution. In asexual populations, the
identification of beneficial alleles is confounded by the presence of genetically linked …

Ploidy varies considerably in nature. However, our understanding of the impact of ploidy on
adaptation is incomplete. Many microbial evolution experiments characterize adaptation in …

A common misconception is that evolution is a linear ‘march of progress’, where each
organism along a line of descent is more fit than all those that came before it. Rejecting this …

Identification of adaptive targets in experimental evolution typically relies on extensive replication
and genetic reconstruction. An alternative approach is to directly assay all mutations in …

Colonization of vacant environments may catalyze adaptive diversification and be followed
by competition within the nascent community. How these interactions ultimately stabilize and …

Many bacteria cycle between sessile and motile forms in which they must sense and respond
to internal and external signals to coordinate appropriate physiology. Maintaining fitness …

Understanding how genes interact is a central challenge in biology. Experimental evolution
provides a useful, but underutilized, tool for identifying genetic interactions, particularly those …

Natural environments are rarely static; rather selection can fluctuate on timescales ranging
from hours to centuries. However, it is unclear how adaptation to fluctuating environments …