Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable
heterogeneity. We have recently identified recurrent H3F3A mutations affecting two …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

The plant Arabidopsis thaliana occurs naturally in many different habitats throughout
Eurasia. As a foundation for identifying genetic variation contributing to adaptation to diverse …

Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(…

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain
stem. It is the most common malignant brain tumour in children, and shows tremendous …

Pilocytic astrocytoma, the most common childhood brain tumor 1 , is typically associated with
mitogen-activated protein kinase (MAPK) pathway alterations 2 . Surgically inaccessible …

Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …

Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified
in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups …

We have extended our understanding of the molecular biology that underlies adult glioblastoma
over many years. By contrast, high-grade gliomas in children and adolescents have …

Despite the histological similarity of ependymomas from throughout the neuroaxis, the
disease likely comprises multiple independent entities, each with a distinct molecular …