User profiles for Sebastian H Bitzenhofer

Sebastian H. Bitzenhofer

University Medical Center Hamburg-Eppendorf
Verified email at zmnh.uni-hamburg.de
Cited by 639

[HTML][HTML] Layer-specific optogenetic activation of pyramidal neurons causes beta–gamma entrainment of neonatal networks

SH Bitzenhofer, J Ahlbeck, A Wolff, JS Wiegert… - Nature …, 2017 - nature.com
Coordinated activity patterns in the developing brain may contribute to the wiring of neuronal
circuits underlying future behavioural requirements. However, causal evidence for this …

Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

SH Bitzenhofer, EA Westeinde, HXB Zhang… - Elife, 2022 - elifesciences.org
Olfactory information is encoded in lateral entorhinal cortex (LEC) by two classes of layer 2 (L2)
principal neurons: fan and pyramidal cells. However, the functional properties of L2 cells …

Gamma activity accelerates during prefrontal development

SH Bitzenhofer, JA Pöpplau, I Hanganu-Opatz - elife, 2020 - elifesciences.org
Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma
rhythms have been extensively studied in the adult prefrontal cortex in the context of cognitive (…

[PDF][PDF] A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice

SH Bitzenhofer, JA Pöpplau, M Chini, A Marquardt… - Neuron, 2021 - cell.com
Disturbed neuronal activity in neuropsychiatric pathologies emerges during development and
might cause multifold neuronal dysfunction by interfering with apoptosis, dendritic growth, …

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

L Jammal Salameh, SH Bitzenhofer, IL Hanganu-Opatz… - Science, 2024 - science.org
The transmission of the heartbeat through the cerebral vascular system causes intracranial
pressure pulsations. We discovered that arterial pressure pulsations can directly modulate …

[PDF][PDF] Resolving and rescuing developmental miswiring in a mouse model of cognitive impairment

…, V Oberländer, X Xu, J Ahlbeck, SH Bitzenhofer… - Neuron, 2020 - cell.com
Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal
networks. This dysfunction emerges during early development, before a detectable …

[HTML][HTML] Spindle activity orchestrates plasticity during development and sleep

C Lindemann, J Ahlbeck, SH Bitzenhofer… - Neural …, 2016 - hindawi.com
Spindle oscillations have been described during early brain development and in the adult
brain. Besides similarities in temporal patterns and involved brain areas, neonatal spindle …

[PDF][PDF] Oscillatory activity in developing prefrontal networks results from theta-gamma-modulated synaptic inputs

SH Bitzenhofer, K Sieben, KD Siebert, M Spehr… - Cell reports, 2015 - cell.com
The hippocampus-driven entrainment of neonatal prefrontal circuits in theta-gamma
oscillations contributes to the maturation of cognitive abilities, yet the underlying synaptic …

[HTML][HTML] Tapered fibers combined with a multi-electrode array for optogenetics in mouse medial prefrontal cortex

L Sileo, SH Bitzenhofer, B Spagnolo… - Frontiers in …, 2018 - frontiersin.org
Optogenetics offers many advantages in terms of cell-type specificity, allowing to investigate
functional connectivity between different brain areas at high spatial and neural population …

[PDF][PDF] Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities

YN Chen, JK Kostka, SH Bitzenhofer… - Current Biology, 2023 - cell.com
The interplay between olfaction and higher cognitive processing has been documented in
the adult brain; however, its development is poorly understood. In mice, shortly after birth, …