We present a multiview selective-plane illumination microscope (MuVi-SPIM), comprising two
detection and illumination objective lenses, that allows rapid in toto fluorescence imaging …

Understanding human organ formation is a scientific challenge with far-reaching medical
implications 1 , 2 . Three-dimensional stem-cell cultures have provided insights into human cell …

Control of cell proliferation is a fundamental aspect of tissue formation in development and
regeneration. Cells experience various spatial and mechanical constraints depending on …

Topological structures are effective descriptors of the nonequilibrium dynamics of diverse
many-body systems. For example, motile, point-like topological defects capture the salient …

10.7554/eLife.27454.001 During embryogenesis tissue layers undergo morphogenetic flow
rearranging and folding into specific shapes. While developmental biology has identified key …

The high volumes of data produced by state-of-the-art optical microscopes encumber
research. We developed a method that reduces data size and processing time by orders of …

Mechanical interactions play a crucial role in epithelial morphogenesis, yet understanding
the complex mechanisms through which stress and deformation affect cell behaviour remains …

Morphogenesis, the process through which genes generate form, establishes tissue-scale
order as a template for constructing the complex shapes of the body plan. The extensive …

The neural crest is an embryonic population of multipotent stem cells that form numerous
defining features of vertebrates. Due to lack of reliable techniques to perform transcriptional …

Organs are sculpted by extracellular as well as cell-intrinsic forces, but how collective cell
dynamics are orchestrated in response to environmental cues is poorly understood. Here we …