User profiles for Sebastian J. Arnold

Sebastian Arnold

University of Freiburg, Institute of Pharmacology
Verified email at pharmakol.uni-freiburg.de
Cited by 7701

[PDF][PDF] Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages

…, RG Domingues, H Veiga-Fernandes, SJ Arnold… - Cell, 2014 - cell.com
Innate lymphoid cells (ILCs) are a recently recognized group of lymphocytes that have
important functions in protecting epithelial barriers against infections and in maintaining organ …

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

SJ Arnold, EJ Robertson - Nature reviews Molecular cell biology, 2009 - nature.com
Genetic studies have identified the key signalling pathways and developmentally regulated
transcription factors that govern cell lineage allocation and axis patterning in the early …

[HTML][HTML] Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

…, T Wiech, F Grahammer, SJ Arnold… - The Journal of …, 2010 - Am Soc Clin Investig
Injury and loss of podocytes are leading factors of glomerular disease and renal failure. The
postmitotic podocyte is the primary glomerular target for toxic, immune, metabolic, and …

Pluripotency factors regulate definitive endoderm specification through eomesodermin

AKK Teo, SJ Arnold, MWB Trotter, S Brown… - Genes & …, 2011 - genesdev.cshlp.org
Understanding the molecular mechanisms controlling early cell fate decisions in mammals
is a major objective toward the development of robust methods for the differentiation of …

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone

SJ Arnold, GJ Huang, AFP Cheung, T Era… - Genes & …, 2008 - genesdev.cshlp.org
The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection
neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are …

[HTML][HTML] Brachyury is a target gene of the Wnt/β-catenin signaling pathway

SJ Arnold, J Stappert, A Bauer, A Kispert… - Mechanisms of …, 2000 - Elsevier
To identify target genes of the Wnt/β-catenin signaling pathway in early mouse embryonic
development we have established a co-culture system consisting of NIH3T3 fibroblasts …

Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse

SJ Arnold, UK Hofmann, EK Bikoff, EJ Robertson - 2008 - journals.biologists.com
The T-box transcription factor eomesodermin (Eomes) has been implicated as an important
component in germ layer induction and patterning in vertebrate embryos. In the mouse, …

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

…, S Dräger, EK Bikoff, EJ Robertson, SJ Arnold - Nature cell …, 2011 - nature.com
Instructive programmes guiding cell-fate decisions in the developing mouse embryo are
controlled by a few so-termed master regulators. Genetic studies demonstrate that the T-box …

Cortical and clonal contribution of Tbr2 expressing progenitors in the developing mouse brain

…, S Arora, AFP Cheung, SJ Arnold… - Cerebral …, 2015 - academic.oup.com
The individual contribution of different progenitor subtypes towards the mature rodent
cerebral cortex is not fully understood. Intermediate progenitor cells (IPCs) are key to …

[HTML][HTML] Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo

SJ Arnold, S Maretto, A Islam, EK Bikoff… - Developmental …, 2006 - Elsevier
Three closely related mammalian R-Smads, namely Smad1, Smad5 and Smad8, are
activated by BMP receptors. Here we have taken a genetic approach to further dissect their …