User profiles for Sebastian Kadener

Sebastian Kadener

Associate Professor, Brandeis University
Verified email at brandeis.edu
Cited by 13085

[PDF][PDF] circRNA biogenesis competes with pre-mRNA splicing

…, N Evantal, S Memczak, N Rajewsky, S Kadener - Molecular cell, 2014 - cell.com
Circular RNAs (circRNAs) are widely expressed noncoding RNAs. However, their biogenesis
and possible functions are poorly understood. Here, by studying circRNAs that we …

[PDF][PDF] Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed

…, A Ivanov, M Öhman, D Refojo, S Kadener… - Molecular cell, 2015 - cell.com
Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their
abundance, their function and expression in the nervous system are unknown. Therefore, we …

[PDF][PDF] A slow RNA polymerase II affects alternative splicing in vivo

M De La Mata, CR Alonso, S Kadener, JP Fededa… - Molecular cell, 2003 - cell.com
Abstract Changes in promoter structure and occupation have been shown to modify the
splicing pattern of several genes, evidencing a coupling between transcription and alternative …

[PDF][PDF] Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer

P Cramer, JF Cáceres, D Cazalla, S Kadener, AF Muro… - Molecular cell, 1999 - cell.com
Alternative mRNA splicing of the fibronectin EDI exon is controlled by a purine-rich exonic
splicing enhancer (ESE), postulated as a binding site for SR proteins. By using a transient …

[HTML][HTML] Transcriptional activators differ in their abilities to control alternative splicing

G Nogués, S Kadener, P Cramer, D Bentley… - Journal of Biological …, 2002 - ASBMB
Promoter and enhancer elements can influence alternative splicing, but the basis for this
phenomenon is not well understood. Here we investigated how different transcriptional …

[PDF][PDF] Translation of circRNAs

…, M Landthaler, M Chekulaeva, N Rajewsky, S Kadener - Molecular cell, 2017 - cell.com
Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely
unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing …

Past, present, and future of circ RNA s

IL Patop, S Wüst, S Kadener - The EMBO journal, 2019 - embopress.org
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of them …

[HTML][HTML] Antagonistic effects of T‐Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing

S Kadener, P Cramer, G Nogués, D Cazalla… - The EMBO …, 2001 - embopress.org
Here we investigate the promoter control of alternative splicing by studying two
transcriptional activators on templates under replicating conditions. SV40 large T‐antigen (T‐Ag) …

Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation

S Kadener, JP Fededa, M Rosbash… - Proceedings of the …, 2002 - National Acad Sciences
Promoters and enhancers are cis-acting elements that control gene transcription via complex
networks of protein–DNA and protein–protein interactions. Whereas promoters deal with …

circRNAs in cancer

IL Patop, S Kadener - Current opinion in genetics & development, 2018 - Elsevier
Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes
and, in many cases, are more abundant that the linear product from their hosting gene. …