User profiles for Sebastian Kadener
Sebastian KadenerAssociate Professor, Brandeis University Verified email at brandeis.edu Cited by 13085 |
[PDF][PDF] circRNA biogenesis competes with pre-mRNA splicing
Circular RNAs (circRNAs) are widely expressed noncoding RNAs. However, their biogenesis
and possible functions are poorly understood. Here, by studying circRNAs that we …
and possible functions are poorly understood. Here, by studying circRNAs that we …
[PDF][PDF] Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed
Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their
abundance, their function and expression in the nervous system are unknown. Therefore, we …
abundance, their function and expression in the nervous system are unknown. Therefore, we …
[PDF][PDF] A slow RNA polymerase II affects alternative splicing in vivo
Abstract Changes in promoter structure and occupation have been shown to modify the
splicing pattern of several genes, evidencing a coupling between transcription and alternative …
splicing pattern of several genes, evidencing a coupling between transcription and alternative …
[PDF][PDF] Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer
Alternative mRNA splicing of the fibronectin EDI exon is controlled by a purine-rich exonic
splicing enhancer (ESE), postulated as a binding site for SR proteins. By using a transient …
splicing enhancer (ESE), postulated as a binding site for SR proteins. By using a transient …
[HTML][HTML] Transcriptional activators differ in their abilities to control alternative splicing
Promoter and enhancer elements can influence alternative splicing, but the basis for this
phenomenon is not well understood. Here we investigated how different transcriptional …
phenomenon is not well understood. Here we investigated how different transcriptional …
[PDF][PDF] Translation of circRNAs
Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely
unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing …
unknown function. Here, we show that a subset of circRNAs is translated in vivo. By performing …
Past, present, and future of circ RNA s
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of them …
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of them …
[HTML][HTML] Antagonistic effects of T‐Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing
Here we investigate the promoter control of alternative splicing by studying two
transcriptional activators on templates under replicating conditions. SV40 large T‐antigen (T‐Ag) …
transcriptional activators on templates under replicating conditions. SV40 large T‐antigen (T‐Ag) …
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
Promoters and enhancers are cis-acting elements that control gene transcription via complex
networks of protein–DNA and protein–protein interactions. Whereas promoters deal with …
networks of protein–DNA and protein–protein interactions. Whereas promoters deal with …
circRNAs in cancer
Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes
and, in many cases, are more abundant that the linear product from their hosting gene. …
and, in many cases, are more abundant that the linear product from their hosting gene. …