Psoriasis is a common immune-mediated, chronic, inflammatory skin disease characterized
by hyperproliferation and abnormal differentiation of keratinocytes and infiltration of …

Proinflammatory cytokine signaling in keratinocytes plays a crucial role in the pathogenesis
of psoriasis, a skin disease characterized by hyperproliferation and abnormal differentiation …

Macrophages constitute a first line of pathogen defense by triggering a number of inflammatory
responses and the secretion of various pro-inflammatory cytokines. Recently, we and …

The transcriptional activator IκBζ is a key regulator of psoriasis, but which cells mediate its
pathogenic effect remains unknown. Here we found that IκBζ expression in keratinocytes …

DNA damage and changes in the mitochondrial DNA content have been implicated in ageing
and cancer development. To prevent genomic instability and tumorigenesis, cells must …

IκBζ is a transcriptional factor induced primarily in immune cells upon Toll-like receptor (TLR)
activation that drives important cytokine responses. Recent studies have demonstrated …

Diffuse large B-cell lymphomas (DLBCLs) represent the most frequent B-cell lymphoma and
can be subdivided into two groups by their gene expression profile, the Activated B-cell-like (…

… We would also like to acknowledge the contribution of Sebastian Achter, who classified
typical demand patterns that we use as model input. The authors are very thankful to the editor …

Supply chain (SC) planning in the semiconductor industry is challenged by high
uncertainties on the demand side as well as a complex manufacturing process with non-deterministic …

Past interglacials are of interest to the scientific community as they can be used to study the
behavior of the climate system during times as warm as or slightly warmer than today. Of …