Stress granules (SGs) are transient ribonucleoprotein (RNP) aggregates that form during
cellular stress and are increasingly implicated in human neurodegeneration. To study the …

The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear,
highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we …

RNA-programmed genome editing using CRISPR/Cas9 from Streptococcus pyogenes has
enabled rapid and accessible alteration of specific genomic loci in many organisms. A …

Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2), Huntington's …

Expanded hexanucleotide repeats in the chromosome 9 open reading frame 72 (C9orf72)
gene are the most common genetic cause of ALS and frontotemporal degeneration (FTD). …

Persistent cytoplasmic aggregates containing RNA binding proteins (RBPs) are central to
the pathogenesis of late-onset neurodegenerative disorders such as amyotrophic lateral …

Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative
diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To …

Chronic cellular stress associated with neurodegenerative disease can result in the persistence
of stress granule (SG) structures, membraneless organelles that form in response to …

Deadenylases are best known for degrading the poly(A) tail during mRNA decay. The
deadenylase family has expanded throughout evolution and, in mammals, consists of 12 Mg 2+ -…

Many cellular models aimed at elucidating cancer biology do not recapitulate pathobiology
including tumor heterogeneity, an inherent feature of cancer that underlies treatment …