Temperature profoundly affects the kinetics of biochemical reactions, yet how large molecular
complexes such as the transcription machinery accommodate changing temperatures to …

Progression of RNA polymerase II (RNAPII) transcription relies on the appropriately positioned
activities of elongation factors. The resulting profile of factors and chromatin signatures …

In addition to their annotated transcript, many eukaryotic mRNA promoters produce divergent
noncoding transcripts. To define determinants of divergent promoter directionality, we used …

Noncoding RNA is emerging as an important regulator of gene expression in many organisms.
We are characterizing RNA-mediated chromatin silencing of the Arabidopsis major floral …

The Arabidopsis GNOM gene encodes an ARF GDP/GTP exchange factor involved in
embryonic axis formation and polar localisation of the auxin efflux regulator PIN1. To examine …

Bijvoet’s method, which makes use of anomalous x-ray diffraction or dispersion, is the standard
means of directly determining the absolute (stereochemical) configuration of molecules, …

Antisense transcription is widespread in many genomes; however, how much is functional
is hotly debated. We are investigating functionality of a set of long noncoding antisense …

Most DNA in the genomes of higher organisms does not encode proteins, yet much is transcribed
by RNA polymerase II (RNAPII) into long non-coding RNAs (lncRNAs). The biological …

In most organisms, the maturation of nascent RNAs is coupled to transcription. Unlike in
animals, the RNA polymerase II (RNAPII) transcribes microRNA genes (MIRNAs) as long and …

In animals, cyclin-dependent kinase inhibitors (CKIs) are important regulators of cell cycle
progression. Recently, putative CKIs were also identified in plants, and in previous studies, …