Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which better
therapies are urgently needed. Macrophages enhance metastasis in many cancer types; …

While CRISPR screens are helping uncover genes regulating many cell-intrinsic processes,
existing approaches are suboptimal for identifying extracellular gene functions, particularly …

Macrophages are one of the most abundant immune cells in the tumour microenvironment
of solid tumours and their presence correlates with reduced survival in most cancers. …

Tumor-associated macrophages (TAM) and myofibroblasts are key drivers in cancer that
are associated with drug resistance in many cancers, including pancreatic ductal …

Pancreatic ductal adenocarcinoma (PDAC) patients have a 5-year survival rate of only 8%
largely due to late diagnosis and insufficient therapeutic options. Neutrophils are among the …

The ability of disseminated cancer cells to evade the immune response is a critical step for
efficient metastatic progression. Protection against an immune attack is often provided by the …

… The CSF1/R axis is critical to the differentiation and survival of macrophages, and inhibitors
of this axis have shown reduction of macrophage density in solid tumors in mice and patients …

The desmoplastic reaction observed in many cancers is a hallmark of disease progression
and prognosis, particularly in breast and pancreatic cancer. Stromal-derived extracellular …

Metastatic cancer spread is responsible for most cancer‐related deaths. To colonize a new
organ, invading cells adapt to, and remodel, the local extracellular matrix (ECM), a network of …

… Sebastian R Nielsen, Valeria Quaranta, Andrea Linford, Perpetua Emeagi, Carolyn
Rainer, Almudena Santos, Lucy Ireland, Takao Sakai, Keiko Sakai, Yong-Sam Kim …