Inhibiting interleukin 36 receptor signaling reduces fibrosis in mice with chronic intestinal inflammation

…, J Zheng, P Baum, S Meyer, S Schürmann… - Gastroenterology, 2019 - Elsevier
Background & Aims Intestinal fibrosis is a long-term complication in inflammatory bowel
diseases (IBD) that frequently results in functional damage, bowel obstruction, and surgery. …

Label‐free multiphoton endomicroscopy for minimally invasive in vivo imaging

…, M Waldner, O Friedrich, S Schürmann - Advanced …, 2019 - Wiley Online Library
Multiphoton microscopy of cellular autofluorescence and second harmonic generation from
collagen facilitates imaging of living cells and tissues without the need for additional …

[HTML][HTML] Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging

…, S Heuke, M Vieth, O Friedrich, S Schürmann… - Scientific Reports, 2016 - nature.com
Assessing disease activity is a prerequisite for an adequate treatment of inflammatory bowel
diseases (IBD) such as Crohn’s disease and ulcerative colitis. In addition to endoscopic …

[HTML][HTML] Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice

…, C Pollmann, B Reischl, A Buttgereit, S Schürmann… - Scientific reports, 2017 - nature.com
In striated muscle, desmin intermediate filaments interlink the contractile myofibrillar apparatus
with mitochondria, nuclei, and the sarcolemma. The desmin network’s pivotal role in …

[PDF][PDF] Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils

S Schürmann, F Von Wegner, RHA Fink, O Friedrich… - Biophysical journal, 2010 - cell.com
The second harmonic generation (SHG) signal intensity sourced from skeletal muscle myosin
II strongly depends on the polarization of the incident laser beam relative to the muscle …

[PDF][PDF] Estimating the 3D pore size distribution of biopolymer networks from directionally biased data

…, S Münster, C Metzner, P Krauss, S Schürmann… - Biophysical journal, 2013 - cell.com
The pore size of biopolymer networks governs their mechanical properties and strongly
impacts the behavior of embedded cells. Confocal reflection microscopy and second harmonic …

Políticas TIC en educación en América Latina: más allá del modelo 1: 1

MT Lugo, VE Kelly, S Schurmann - Campus Virtuales, 2015 - uajournals.com
El artículo presenta un estado de situación de las políticas de integración de TIC en los
sistemas educativos de América Latina a partir de relevamientos recientes realizados por …

[HTML][HTML] Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection

…, T Leupold, L Kreiss, M Waldner, S Schürmann… - Nature …, 2022 - nature.com
Group 3 innate lymphoid cells (ILC3s) are crucial mediators of immunity and epithelial
barrier function during immune responses against extracellular bacteria. Here, we identify …

Mechano-regulation of the beating heart at the cellular level–mechanosensitive channels in normal and diseased heart

O Friedrich, S Wagner, AR Battle, S Schürmann… - Progress in biophysics …, 2012 - Elsevier
The heart as a contractile hollow organ finely tunes mechanical parameters such as stroke
volume, stroke pressure and cardiac output according to filling volumes, filling pressures via …

[HTML][HTML] Natural NADH and FAD autofluorescence as label-free biomarkers for discriminating subtypes and functional states of immune cells

…, O Friedrich, MF Neurath, S Schürmann… - International journal of …, 2022 - mdpi.com
Immune cell activity is a major factor for disease progression in inflammatory bowel diseases
(IBD). Classifying the type and functional state of immune cells is therefore crucial in clinical …