Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants (TTNtvs)]
are the most common genetic cause for dilated cardiomyopathy (DCM), a major …

Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the
isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional …

Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …

Fibrosis is a common pathology in cardiovascular disease 1 . In the heart, fibrosis causes
mechanical and electrical dysfunction 1 , 2 and in the kidney, it predicts the onset of renal …

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an
abundant structural, sensory, and signaling filament in muscle) as a common cause of end-…

Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are
also encountered in ∼1% of the general population, where they may be silent, perhaps …

One of the greatest challenges in cell therapy is to minimally invasively deliver a large quantity
of viable cells to a tissue of interest with high engraftment efficiency. Low and inefficient …

The ability to explore cell signalling and cell-to-cell communication is essential for understanding
cell biology and developing effective therapeutics. However, it is not yet possible to …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease where invasive
pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that …

Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in
dilated cardiomyopathy (DCM), a major cause of chronic heart failure, presumably through …