User profiles for Sebastian Werneburg
 | Sebastian Werneburg, Ph.D.University of Michigan, Michigan Medicine Verified email at umich.edu Cited by 1322 |
[PDF][PDF] Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease
S Werneburg, J Jung, RB Kunjamma, SK Ha… - Immunity, 2020 - cell.com
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system.
While work has focused on myelin and axon loss in MS, less is known about mechanisms …
While work has focused on myelin and axon loss in MS, less is known about mechanisms …
Engineering of complex protein sialylation in plants
…, S Werner, H Thiesler, S Werneburg… - Proceedings of the …, 2016 - National Acad Sciences
Sialic acids (Sias) are abundant terminal modifications of protein-linked glycans. A unique
feature of Sia, compared with other monosaccharides, is the formation of linear homo-…
feature of Sia, compared with other monosaccharides, is the formation of linear homo-…
Neuronal vulnerability and multilineage diversity in multiple sclerosis
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing–remitting disease
course at early stages, distinct lesion characteristics in cortical grey versus subcortical white …
course at early stages, distinct lesion characteristics in cortical grey versus subcortical white …
Whole-genome sequencing reveals that variants in the interleukin 18 receptor accessory protein 3′ UTR protect against ALS
…, G Beck, E Ainbinder, S Ben-Dor, S Werneburg… - Nature …, 2022 - nature.com
The noncoding genome is substantially larger than the protein-coding genome but has been
largely unexplored by genetic association studies. Here, we performed region-based rare …
largely unexplored by genetic association studies. Here, we performed region-based rare …
A microglia-cytokine axis to modulate synaptic connectivity and function
S Werneburg, PA Feinberg, KM Johnson… - Current opinion in …, 2017 - Elsevier
Highlights • Microglial cytokine signaling regulates axon outgrowth and synaptogenesis. •
CX3CR1 regulates microglial recruitment to synapses necessary for synaptic maturation. • …
CX3CR1 regulates microglial recruitment to synapses necessary for synaptic maturation. • …
Polysialic acid: versatile modification of NCAM, SynCAM 1 and neuropilin-2
M Mühlenhoff, M Rollenhagen, S Werneburg… - Neurochemical …, 2013 - Springer
The glycan polysialic acid is well-known as a unique posttranslational modification of the
neural cell adhesion molecule NCAM. Despite remarkable acceptor specificity, however, a few …
neural cell adhesion molecule NCAM. Despite remarkable acceptor specificity, however, a few …
Polysialylation and lipopolysaccharide‐induced shedding of E‐selectin ligand‐1 and neuropilin‐2 by microglia and THP‐1 macrophages
S Werneburg, FFR Buettner, L Erben, M Mathews… - Glia, 2016 - Wiley Online Library
Microglia are tissue macrophages and mediators of innate immune responses in the brain.
The protein‐modifying glycan polysialic acid (polySia) is implicated in modulating microglia …
The protein‐modifying glycan polysialic acid (polySia) is implicated in modulating microglia …
Polysialic acid on SynCAM 1 in NG2 cells and on neuropilin‐2 in microglia is confined to intracellular pools that are rapidly depleted upon stimulation
NG2 cells comprise a heterogeneous precursor population but molecular markers distinguishing
between the assumed NG2 cell subpopulations are lacking. Previously, we described …
between the assumed NG2 cell subpopulations are lacking. Previously, we described …
Polysialic acid controls NCAM signals at cell–cell contacts to regulate focal adhesion independent from FGF receptor activity
K Eggers, S Werneburg, A Schertzinger… - Journal of cell …, 2011 - journals.biologists.com
The polysialic acid (polySia) modification of the neural cell adhesion molecule NCAM is a
key regulator of cell migration. Yet its role in NCAM-dependent or NCAM-independent …
key regulator of cell migration. Yet its role in NCAM-dependent or NCAM-independent …
Polysialylation at early stages of oligodendrocyte differentiation promotes myelin repair
S Werneburg, HLS Fuchs, I Albers… - Journal of …, 2017 - Soc Neuroscience
Polysialic acid is a glycan modification of the neural cell adhesion molecule (NCAM) produced
by the polysialyltransferases ST8SIA2 and ST8SIA4. Polysialic acid has been detected in …
by the polysialyltransferases ST8SIA2 and ST8SIA4. Polysialic acid has been detected in …