User profiles for Sebastiano Battaglia
Sebastiano BattagliaRoswell Park Cancer Institute - Buffalo (NY) Verified email at roswellpark.org Cited by 1341 |
[HTML][HTML] T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
Immune checkpoint inhibitors (ICI) have revolutionized treatment for various cancers;
however, durable response is limited to only a subset of patients. Discovery of blood-based …
however, durable response is limited to only a subset of patients. Discovery of blood-based …
Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses
…, R Gunawan, MA Cheever, S Battaglia… - Science translational …, 2022 - science.org
To uncover underlying mechanisms associated with failure of indoleamine 2,3-dioxygenase
1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical …
1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical …
Transcription factor co‐repressors in cancer biology: roles and targeting
S Battaglia, O Maguire… - International Journal of …, 2010 - Wiley Online Library
Normal transcription displays a high degree of flexibility over the choice, timing and magnitude
of mRNA expression levels that tend to oscillate and cycle. These processes allow for …
of mRNA expression levels that tend to oscillate and cycle. These processes allow for …
[HTML][HTML] Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer
Background Efficient identification of neoantigen-specific T-cell responses in epithelial
ovarian cancer (EOC) remains a challenge. Existing investigations of spontaneous T-cell …
ovarian cancer (EOC) remains a challenge. Existing investigations of spontaneous T-cell …
[HTML][HTML] IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation
A Amobi-McCloud, R Muthuswamy, S Battaglia… - Frontiers in …, 2021 - frontiersin.org
The immunoregulatory enzyme, indoleamine 2,3-dioxygenase (IDO1) and the PD-1/PD-L1
axis are potent mechanisms that impede effective anti-tumor immunity in ovarian cancer. …
axis are potent mechanisms that impede effective anti-tumor immunity in ovarian cancer. …
Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns
The current study investigated transcriptional distortion in prostate cancer cells using the
vitamin D receptor (VDR) as a tool to examine how epigenetic events driven by corepressor …
vitamin D receptor (VDR) as a tool to examine how epigenetic events driven by corepressor …
Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant
Multiple candidate gene-association studies of non-HLA single-nucleotide polymorphisms (SNPs)
and outcomes after blood or marrow transplant (BMT) have been conducted. We …
and outcomes after blood or marrow transplant (BMT) have been conducted. We …
Epigenetic control of a VDR-governed feed-forward loop that regulates p21 ( waf1/cip1 ) expression and function in non …
In non-malignant RWPE-1 prostate epithelial cells signaling by the nuclear receptor Vitamin
D Receptor (VDR, NR1I1) induces cell cycle arrest through targets including CDKN1A (…
D Receptor (VDR, NR1I1) induces cell cycle arrest through targets including CDKN1A (…
[HTML][HTML] Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in …
…, K Attwood, CD Morrison, AJ Makowski, S Battaglia… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Epidemiologic studies implicate vitamin D status as a factor that influences growth of EGFR
mutant lung cancers. However, laboratory based evidence of the biological effect of vitamin …
mutant lung cancers. However, laboratory based evidence of the biological effect of vitamin …
Elevated NCOR1 disrupts PPARα/γ signaling in prostate cancer and forms a targetable epigenetic lesion
S Battaglia, O Maguire, JL Thorne, LB Hornung… - …, 2010 - academic.oup.com
The loss of anti-proliferative responsiveness in prostate cancer cell lines toward ligands for
vitamin D receptor, retinoic acid receptors/retinoid X receptors and peroxisome proliferator …
vitamin D receptor, retinoic acid receptors/retinoid X receptors and peroxisome proliferator …