Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA
…, A Round, S Dechavanne… - Proceedings of the …, 2010 - National Acad Sciences
Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …
[HTML][HTML] Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin
…, N Fievet, G Gbaguidi, S Dechavanne… - The American journal …, 2011 - ncbi.nlm.nih.gov
Although consequences of malaria in pregnancy are well known, the period of pregnancy in
which infection has the highest impact is still unclear. In Benin, we followed up a cohort of …
which infection has the highest impact is still unclear. In Benin, we followed up a cohort of …
PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study
…, AT Konate, C Campion, S Dechavanne… - The Lancet Infectious …, 2020 - thelancet.com
Background PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy. …
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy. …
[HTML][HTML] Var2CSA minimal CSA binding region is located within the N-terminal region
A Srivastava, S Gangnard, S Dechavanne, F Amirat… - PloS one, 2011 - journals.plos.org
Var2CSA, a key molecule linked with pregnancy-associated malaria (PAM), causes sequestration
of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by adhesion to …
of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by adhesion to …
[HTML][HTML] Disruption of Var2csa Gene Impairs Placental Malaria Associated Adhesion Phenotype
NK Viebig, E Levin, S Dechavanne, SJ Rogerson… - PloS one, 2007 - journals.plos.org
Infection with Plasmodium falciparum during pregnancy is one of the major causes of malaria
related morbidity and mortality in newborn and mothers. The complications of pregnancy-…
related morbidity and mortality in newborn and mothers. The complications of pregnancy-…
Duffy antigen is expressed during erythropoiesis in Duffy-negative individuals
C Dechavanne, S Dechavanne, J Bosch, S Metral… - Cell Host & Microbe, 2023 - cell.com
The erythrocyte silent Duffy blood group phenotype in Africans is thought to confer resistance
to Plasmodium vivax blood-stage infection. However, recent studies report P. vivax …
to Plasmodium vivax blood-stage infection. However, recent studies report P. vivax …
[HTML][HTML] Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP
…, C Roesch, ND Salinas, S Dechavanne… - Nature …, 2019 - nature.com
The Plasmodium vivax Duffy-binding protein (DBP) is a prime target of the protective immune
response and a promising vaccine candidate for P. vivax malaria. Naturally acquired …
response and a promising vaccine candidate for P. vivax malaria. Naturally acquired …
Placental cytokine and chemokine profiles reflect pregnancy outcomes in women exposed to Plasmodium falciparum infection
…, V Briand, S Ibitokou, S Dechavanne… - Infection and …, 2014 - Am Soc Microbiol
Pregnancy-associated malaria (PAM) can lead to severe complications for both mother and
baby. Certain placental cytokine/chemokine profiles have been shown to reflect poor …
baby. Certain placental cytokine/chemokine profiles have been shown to reflect poor …
[HTML][HTML] Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates
M Avril, MJ Hathaway, A Srivastava, S Dechavanne… - PloS one, 2011 - journals.plos.org
The high molecular weight, multidomain VAR2CSA protein mediating adhesion of Plasmodium
falciparum-infected erythrocytes in the placenta is the leading candidate for a pregnancy …
falciparum-infected erythrocytes in the placenta is the leading candidate for a pregnancy …
[HTML][HTML] Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions
S Gangnard, A Lewit-Bentley, S Dechavanne… - Scientific reports, 2015 - nature.com
The human malaria parasite, Plasmodium falciparum, is able to evade spleen-mediated
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …