User profiles for Sebastien Foulqier

Sébastien Foulquier

Maastricht University - Cardiovascular Research Institute Maastricht
Verified email at maastrichtuniversity.nl
Cited by 879

WNT signaling in cardiac and vascular disease

S Foulquier, EP Daskalopoulos, G Lluri… - Pharmacological …, 2018 - ASPET
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated
by multiple signaling molecules. WNT signaling is critically important for developmental …

[HTML][HTML] AT2 Receptor and Tissue Injury: Therapeutic Implications

P Namsolleck, C Recarti, S Foulquier… - Current hypertension …, 2014 - Springer
The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the …

[HTML][HTML] Vessel-associated immune cells in cerebrovascular diseases: from perivascular macrophages to vessel-associated microglia

…, T Mizuno, HWM Steinbusch, S Foulquier - Frontiers in …, 2019 - frontiersin.org
Cerebral small vessels feed and protect the brain parenchyma thanks to the unique features
of the blood–brain barrier. Cerebrovascular dysfunction is therefore seen as a detrimental …

[HTML][HTML] Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment

…, Z Ahmed, WM Blankesteijn, S Foulquier - Acta neuropathologica …, 2023 - Springer
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain
barrier impairments which play a key role in the development of white matter lesions. …

[HTML][HTML] Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension

…, EA Biessen, RJ van Oostenbrugge, S Foulquier - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Hypertension is a major risk factor for cerebral small vessel disease, the most
prevalent cause of vascular cognitive impairment. As we have shown, hypertension induced by …

Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice

S Foulquier, P Namsolleck, BT Van Hagen… - Hypertension …, 2018 - nature.com
The causal relation between hypertension and cerebral small vessel disease (cSVD) remains
elusive, and appropriate animal models are scarce. We aimed to assess the relevance of …

[HTML][HTML] Combined angiotensin receptor modulation in the management of cardio-metabolic disorders

L Paulis, S Foulquier, P Namsolleck, C Recarti… - Drugs, 2016 - Springer
Cardiovascular and metabolic disorders, such as hypertension, insulin resistance, dyslipidemia
or obesity are linked with chronic low-grade inflammation and dysregulation of the renin–…

[HTML][HTML] A systematic review of WNT signaling in endothelial cell oligodendrocyte interactions: potential relevance to cerebral small vessel disease

…, Z Ahmed, D Fulton, WM Blankesteijn, S Foulquier - Cells, 2020 - mdpi.com
Key pathological features of cerebral small vessel disease (cSVD) include impairment of the
blood brain barrier (BBB) and the progression of white matter lesions (WMLs) amongst …

[HTML][HTML] Methylglyoxal, a highly reactive dicarbonyl compound, as a threat for blood brain barrier integrity

E Berends, RJ van Oostenbrugge, S Foulquier… - Fluids and Barriers of …, 2023 - Springer
The brain is a highly metabolically active organ requiring a large amount of glucose. Methylglyoxal
(MGO), a by-product of glucose metabolism, is known to be involved in microvascular …

[HTML][HTML] The AT1/AT2 Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System

M Colin, C Delaitre, S Foulquier, F Dupuis - Molecules, 2023 - mdpi.com
The AT 1 receptor has mainly been associated with the pathological effects of the renin-angiotensin
system (RAS) (eg, hypertension, heart and kidney diseases), and constitutes a major …