Modeling stochasticity in gene regulatory networks is an important and complex problem in
molecular systems biology. To elucidate intrinsic noise, several modeling strategies such as …

Background Adverse drug reactions (ADRs) are one of the leading causes of morbidity and
mortality in health care. Understanding which drug targets are linked to ADRs can lead to the …

Background With the global emergence of multi-drug resistant strains of Mycobacterium
tuberculosis, new strategies to treat tuberculosis are urgently needed such as therapeutics …

Pseudomonas aeruginosa is a metabolically flexible member of the Gammaproteobacteria.
Under anaerobic conditions and the presence of nitrate, P. aeruginosa can perform (…

Background & Aims Immune checkpoint inhibitors (ICIs) are associated with immune-related
adverse events (irAEs) which are more severe when ICIs are used in combination. We …

Early diagnosis of drug-induced liver injury (DILI) continues to be a major hurdle during drug
development and postmarketing. The objective of this study was to evaluate the diagnostic …

Dysregulation of iron metabolism in cancer is well documented and it has been suggested
that there is interdependence between excess iron and increased cancer incidence and …

While much is known about the enzymes that deposit and remove epigenetic modifications,
less is known about the trans-acting system that determines when and where these …

Adoption of mobile technologies by governmental units not only benefits the parties who use
these services, but also can have a positive impact on the internal workings of public sector …

The degradation tag (dTAG) system for target protein degradation can remove proteins from
biological systems without the drawbacks of some genetic methods, such as slow kinetics, …